Extremely bright, water-soluble, thiol-reactive label containing one maleimide group. The ideal label for proteins and other thiol-modified biomolecules including oligonucleotides.
Advantages
Perfectly suited for excitation with 635, 640, and 650-nm diode lasers.
Low quenching tendency at high dye-to-protein ratios compared to other labels e.g. Cy5.
Large Stokes’shiftof ~44 nm (about twice that of Cy5 or Alexa 647).
Considerably higher photostabilitycompared to fluorescein or other cyanine dyes (Cy5, Alexa or ATTO dyes).
High chemical stability against oxidation with peroxides or other oxygen species.
Several times longer fluorescence lifetime (t ~ 3 ns)compared to Cy5 or Alexa 647 (t ~ 1 ns).
Extremely bright label: most sensitive organic fluorescent label for proteins currently on the market for the 647-nm Kr-ion laser line.