SeTau dyes near ideal in vivo 2P imaging characteristics reported by group at Harvard Medical School
Recently the group of Prof. Weissleder at the Harvard Medical School has reported on two-photon beta cell specific in vivo imaging probes based on GLP1R targeting peptides labelled with a SETA 2-photon squaraine rotaxane: "Among the three compounds of potential interest, we found quite unexpectedly that a squaraine-rotaxane conjugate (2PEx-647, SeTau-647, K9-4148) had near ideal in vivo imaging characteristics".
Susan M. Clardy et al. "Two-photon imaging of pancreatic beta cells in real time in vivo". Technology 04, 130 (2016).
| Excitation Light Sources | Characteristics | ||||||||||||||||||||
| Product Number (Specs Sheet) |
Product Name (Product Info) |
Target Group | 380 | 405 | 436 | 488 | 532 | 594 | 635 | 650 | 680 | 700 | 750 | 780 | Medium | λ abs [nm] |
ε [M –1 cm–1] |
λ em [nm] |
QY [%] |
FLT [ns] |
Buy |
| K9-4119 | SeTau-665-NHS | NH2 | • | • | • | PB 7.4 | 664 | 160000 | 712 | 53 | 3.1 | ||||||||||
| K9-4148 | SeTau-647-Maleimide | SH | • | • | PB 7.4 | 648 | 200000 | 692 | 45 | 3.2 | |||||||||||
| K9-4149 | SeTau-647-NHS | NH2 | • | • | PB 7.4 | 649 | 200000 | 695 | 61 | 3.2 | |||||||||||
| K9-4169 | SeTau-670-NHS | NH2 | • | • | • | PB 7.4 | 673 | 275000 | 694 | 36 | 1.6 | ||||||||||
